Biggest Celebrity Weight-Loss Transformations of 2024 Including Lizzo, Kelly Clarkson, Dave Bautista, and More Shrinking Stars

Speaking in an interview with Fox News Digital, Carnie Wilson revealed she lost nearly 50 pounds without using Ozempic, a medication for treating type 2 diabetes.

"I personally was too scared for any side effects, gastrointestinal side effects. My doctor warned me. He said, 'This is an option if you want to do it, but I am warning you that it has not been around enough for the way many people are using this, and that is for weight loss,'" Wilson explained.

The 56-year-old songstress quoted her doctor, who revealed other patients sought treatment due to side effects from the drug.

Instead of taking semaglutide and other similar medications, Wilson opted to eliminate sugar, butter and gluten from her diet while moving more.

For years, Christina Aguilera has dealt with Ozempic rumors – and constantly denied them – due to her slimmed-down figure. She revealed she shed nearly 40 pounds by making healthy choices and exercising more.

In August, the Lady Marmalade singer explained her self-esteem was heavily tied to her body weight and image, and the rumors and comments about her frame pushed her to teach herself to be mature enough "not to give a f---."

She told Glamour: "I started to fill out, and then that was unacceptable because it was like, 'Oh, she's getting thicker.' Then I had industry people: 'They liked your body and how you were as a skinny teenager.'

"I'm not going to take it on. It must be your responsibility to take up your space. Other people's opinions of me are not my business."

For Dave Bautista to achieve a 50-pound weight-loss, he needed to sacrifice "a lot of muscle" but he was "okay with it."

"It's the way I lose weight," he told Kelly Ripa and Mark Consuelos in a July episode of Live With Kelly and Mark, confirming he turned to jiu-jitsu to melt most of his muscle mass.

He added: "I put on all this weight for Knock at the Cabin. I was really big, like over 300lbs."

At 54, rapper Fat Joe successfully lost 200 pounds through diet, exercise and Ozempic.

Before the BET Hip Hop Awards in October, he told Us Weekly, "We just try to eat everything with the least carbs as possible. So, we try to stay away from the bread, the pasta, the rice."

Ozempic also helped him lose weight while managing the symptoms of diabetes, which he was diagnosed with when he was a teenager.

During an appearance on his wife Bunnie Xo's Dumb Blonde podcast on December 16, Jelly Roll opened up about losing 140 pounds after he "walked around like a 550-pound zombie for years."

He revealed: "I'm still morbidly obese. But I'm gonna lose the weight, I'm going to keep getting it off like I have been."

The 40-year-old Son of a Sinner singer credited his active lifestyle for helping him lose weight naturally while also admitting he was petrified of using Ozempic in his journey.

After she was diagnosed with type 2 diabetes in 2017, Kathy Bates changed her diet and lifestyle while allowing Ozempic to assist her in her weight-loss journey.

"I ate because I was afraid, and I ate because it was a FU to my self-esteem," the American Horror Story actress, who lost 100 pounds, said.

She continued: "[Diabetes] runs in my family, and I'd seen what my father had gone through. He had had a leg amputation. One of my sisters is dealing with it very seriously, and it terrified me. It scared me straight."

In January, Kelly Clarkson revealed her incredible weight-loss journey started after receiving a pre-diabetic diagnosis. From there, she started following wellness practices and changed her diet. She also began taking medication, though she clarified it was not Ozempic.

"But it's something that aids in helping break down the sugar. Obviously, my body doesn't do it right," Clarkson told Whoopi Goldberg in a May episode of The Kelly Clarkson Show.

With the help of diet and exercise, Lizzo proudly flaunted her new look.

She told The New York Times: "I don't really see it because if anyone who's on a natural weight-loss journey knows, losing weight is actually the slowest thing in the world and you don't really notice it until you notice it.

"Also the scale's not really moving. But anyway, that doesn't matter. I'm super proud of my current lifestyle."

Aside from walking and Pilates, the hitmaker also began focusing on her calorie intake, in addition to strength training.

Meghan Trainor just "made you look" even more following her 60-pound weight-loss.

During her appearance on Today, the Dear Future Husband singer said she found her go-to fitness routine that improved her health.

"I didn't know lifting weights would change my life so much," she revealed.