The eight-bedroom estate that she sold for $19 million last year was engulfed in a raging blaze for over 90 minutes before firefighters could control it.
More than 100 firefighters were on the scene in the elite gated community with one of the officers sustaining injury.
The fire broke out around 6.30 pm Friday with reports that the blaze started in the attic and spread through the roof before ripping through the lower floors.
The 17,000 sq. ft. home was the venue for Lisa's daughter Pandora’s wedding earlier this year.
"I'm sorry for the new owners," Vanderpump told NBC4. "I mean, they paid a lot of money for it."