Christina Applegate Didn't 'Look in the Mirror for a Year' After Dropping 50 Pounds Amid Battle With MS
Christina Applegate describes her weight loss as 'dangerous' and 'scary.'
March 3 2026, Published 11:12 a.m. ET
Christina Applegate didn't "look in the mirror for a year" after dropping 50 pounds amid her battle with MS, RadarOnline.com can reveal.
The weight loss she endured was so significant that Applegate describes it as "dangerous" and "scary" in her new book, You With the Sad Eyes.
Christina Applegate Discusses Her Weight Loss From MS
Christina Applegate's weight loss 'bothered' her 'more than' MS at times, she notes.
Applegate notes, "sometimes the weight loss bothered me more than the disease," which caused her not to want to see her reflection.
She was then put on a clear-liquid diet due to stomach issues, and that's when she claims "everything just dropped off of me."
"Within seven months, all of it was gone, and I was down by 50 pounds or more. These days, my legs are tinier than they’ve ever been," she writes.
MS Has Given Christina Applegate Stomach Issues
Christina Applegate's MS has caused her to have stomach issues.
Applegate, who famously starred on Married With Children, was diagnosed with MS in 2021.
She explains MS is what causes stomach issues that led her to lose so many pounds.
"The illness has given me serious stomach issues," she reveals. "As I write this, there are tamales downstairs that are the best tamales you could ever have – I want to eat five of them right now, I’m so hungry – but I know if I do, I’ll probably end up in the ER again, as I have so many times recently."
Christina Applegate Insists the Sickness Will Not Win
Christina Applegate writes she's 'managed to create a much healthier place' regarding her 'relationship with food.'
While she claims she has "managed to create a much healthier place" regarding her "relationship with food," she admits MS has affected her, particularly on her legs, which she states are "scary-looking."
She also insists she now has "no muscles" on her legs but rather "just sticks."
"But there’s still that little voice in my head saying, 'You're really skinny. You have the legs you always wanted. Good for you'," she writes. "This is the sickness. But she’s not going to win."
After being diagnosed with the debilitating disease, Applegate appeared on The Kelly Clarkson Show in 2022 to explain how she came to find out she had it.
"I didn’t know what was happening to me," she shared. "I couldn't walk. They had to use a wheelchair to get me to the set [of Dead to Me]. I was freaking out. Someone was like, 'You need an MRI.'"
Christina Applegate's Ongoing MS Battle
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Christina Applegate was diagnosed with MS in 2021.
Before appearing on Clarkson's show, Applegate gave an interview to The New York Times.
In it, she revealed she had to use a cane to walk and had gained 40 pounds during her early battle with MS.
"This is the first time anyone’s going to see me the way I am," she shared. "I'm never going to accept this. I'm pissed."
Applegate's MS has continued to progress, and she recently divulged she's been confined to her bed from it.
In an interview with People last month, she noted she wants to take her daughter to school as it's her "favorite thing to do."
"It's the only time we have together by ourselves. I tell myself, 'Just get her there safely and get home so you can get back into bed.' And that's what I do," she sadly said. "My life isn't wrapped up with a bow. People's lives, sorry for lack of a better term, f------ suck sometimes. So I’m being as honest and raw as I possibly can."
