The 25-year-old rapper told the radio station, "No, I'm not dating Kylie -- I wanna be clear to everybody, I didn't leave my family to be with Kylie -- that's ridiculous."
He said that there's mass speculation over him and the 17-year-old "because of what people make it seem," whereas the truth is, he's known the family for a long time.
"I was friends with Scott Disick and her family for years, so me hanging out with them was nothing new -- people just want to make a story out of it."
Watch the video on RadarOnline.com
He said that some of the media reports he's seen about him and Kylie are "the craziest things I ever heard of."
Rose earlier lashed out at Tyga on the same radio show, saying the hip-hop artist "should be ashamed of himself" for being involved with the young socialite.
"He has a beautiful woman, and a baby, and left that for a 16-year-old who just turned 17."
Readers, what do you make of Tyga's response?