The 56-year-old sister of the late Michael Jackson said in a statement, "I am so pleased to be working with television legend Oprah Winfrey and to be a part of the OWN family.
"This will be one of the most exciting adventures of my life."
Sheri Salata, OWN's co-president, said the network is "delighted" to be in business with the Jackson sibling, who has kept a relatively low profile in the wake of her family's recent squabbles over Michael's estate.
LaToya is no stranger to the leering cameras of reality TV, having appeared on Celebrity Apprentice and Big Brother UK.
Michael Jackson's Former Nanny: He Tried To Protect His Kids From This Drama