The two joined Gerard Butler, Woody Harrelson, Mike Myers and Edward Norton who came away unscathed from the rough-and-tumble contest played in Manchester, England.
Ferrell, 44, had never tackled before and ended up in obvious pain with a leg injury.
Hell’s Kitchen star Gordon Ramsay was soon to follow, and The New York Post reports that the celebrity chef had to be given oxygen before being stretchered off.
Later in the day, Ramsay tweeted: "Thx 4 all the messages…. Out of hospital after receiving amazing care from medics at ground & hospital. Bit sore but fine.”
The match -- and the celebs' injuries -- were all for a good cause. More than $6.4 million was raised for UNICEF.