Giuliana Rancic left her anchor job at E! News Wednesday, the network announced, adding she will continue to work on Fashion Police and Live from the Red Carpet.
She added that she'll continue in both of her other positions at the network, as well as personal business endeavors such as her wine and clothing line, and producing her Oxygen show Rich in Faith.
"This is such a thrilling time for me and I thank the gang at E! for understanding my desire to embark on this next chapter in my life," said Rancic, a cancer survivor.
Rancic "played an instrumental role in building E! News into a global entertainment news powerhouse," E! general manager Adam Stotsky said, adding that he's "delighted" she'll remain with the organization in the other positions.
Watch the video on RadarOnline.com
Her last appearance on E! News will be Aug. 10.
It's been a rocky year for Rancic, whose controversial remarks about Zendaya's dreadlocked Oscars hairdo triggered a sequence of events that led to Fashion Police going on hiatus, with Kelly Osbourne and Kathy Griffin both leaving the program.