It didn't open to the kind of numbers that had been hoped for but the animated Rango took first place at the weekend box office, bringing in an estimated $38 million in tickets.
Depp is the voice of a chameleon named Rango. Isla Fisher, Abigail Breslin and Depp's good buddy Harry Dean Stanton also lent their voices to the flick.
VIDEO: Johnny Depp Lets His Inner Kid Out While Voicing Rango
Matt Damon's The Adjustment Bureau opened in second place. Its $21 million in ticket sales was actually slightly higher than had been predicted.