Howard Stern asked the comedian if he recently spoke with the actress following her recent arrests, rehab check-ins and hospitalizations.
Spade replied he spoke to Locklear when she reached out to him following his sister-in-law Kate Spade's tragic June 5 suicide death.
"Yeah she texted me about Katie, and I texted her. And I was checking on her recently," Spade admitted. "She's always so sweet and so nice and I loved hanging out with her."
Spade, 54, added that he hoped to hang out with her soon.
"It's funny because I think sometimes it sounds condescending to say 'Oh, I hope you're okay.' I don't really say that," Spade explained. "But I just let her know that I think about her and that I'd love to see her and love to have lunch with her one day. She was always so funny and so cool. She was great."
As Radar previously reported, Locklear, 56, has been arrested twice for allegedly hitting police officers this year.
In June, she was rushed to the hospital and placed on a psychiatric evaluation after threatening to kill herself.
She has since checked herself into long-term treatment.
Locklear currently faces up to 10 years in prison for her February arrest. She pleaded not guilty to the charges.
She will return to court for her June arrest on August 23.
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