Aniston, 48, and Handler, 42, became close after the former Friends star appeared on Handler’s late-night talk show.
The usually snarky host gushed about Jen’s new guy, calling him “the greatest guy ever” and saying they make “the greatest couple ever.”
Handler was also a guest at Aniston and Theroux’s 2015 wedding.
“He married a f**king lunatic,” she said on her show. Radar readers remember that Pitt was married to Aniston when he reportedly cheated on her with Jolie while filming the movie Mr. and Mrs. Smith.
In the past, Handler has joked that being friends with Aniston is “a burden” but in all seriousness promised her friend, “I wouldn’t screw you over, I just wouldn’t do that.”
But the lovefest seems over now. In a recent interview on The Howard Stern Show, Handler seemingly blabbed about her falling out with Aniston, saying, “If you lie to me or you lie about me, I can’t take that. … I’m a really good friend and I expect the same in return.”
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