The fun-loving picture is part of the magazine's annual Out 100, a list of the most influential men and women in the LGBT community, and each of the celebrities were asked to mimic their favorite famous photos.
Griffin, who looks amazing for 51, had fun with Jackson's daring 1993 bare-breasted pose as Modern Family Jesse star grins cheekily behind her.
According to Out, the pair “couldn't stop from clowning around” during the shoot, and afterwards Ferguson tweeted how his hands would “never be the same.”
In the original photo, Control singer Janet posed with her then unknown husband Renee Elizondo Jr. covering her naked breasts as she flashed her rock-hard abs.
The incredibly sultry shot became the most recognizable cover of the year and cemented 27-year-old Jackson as a true sex symbol.
Also appearing in the special Out issue are Adam Lambert, Sandra Bernhard, Dustin Lance Black and Chaz Bono.
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