Mark your calendar, and stock up on your Kleenex.
Oprah Winfrey's very last show of her syndicated mega-successful chatfest will be Wednesday, May 25.
As RadarOnline.com has previously reported, Winfrey, 57, announced last year that she was ending her multi-Emmy Award winning talk show this year after 25 seasons.
As for who will be the final guests -- the folks at Harpo aren't saying, but we can expect an A-list tribute to the Queen of Talk.
The Oprah Winfrey Show has been in reruns lately; brand new shows return on Thursday, April 7.
Last week, Oprah tweeted: "Hard at work planning the final shows - can't wait to share w/ u all!"
As Winfrey wraps up her show, she's now focusing on her new television network OWN, which premiered in January.