Tragedy has struck Katie Holmes' family.
RadarOnline.com has learned that Katie's brother-in-law died suddenly at age 48. Joseph Jeffrey Fretti, 48, was found dead by a family friend on April 12 in the Sarasota, Fl., home of his mother Shirley.
Fretti is the husband of Katie's oldest sister Tamera, 41. Katie has two other older sisters.
Jeff Fretti was the owner of a funeral home in Toledo, Ohio. He had taken his two young children to visit his 76-year-old mother.
Sarasota Medical Examiner Russell Vega told RadarOnline.com that a cause of death has yet to be determined but doesn't suspect foul play or suicide.
Tamera, who was not along for the trip to Sarasota, flew to Florida to bring her two children back home to Toledo.
A funeral Mass for Fretti is scheduled at Gesu Church in Toledo next Monday. Katie is expected to attend the service for her brother-in-law. It is not known if husband Tom Cruise will also attend.