Odom, who was found unconscious at a Las Vegas brothel in October 2015, claimed Kardashian found out about his drug use two years before their 2011 split.
"I was hiding it for a while, but then I got frustrated and was like, 'f**k it,'" Odom, 37, told Us Weekly. "I was in the man cave she had made for me and she caught me. She was disappointed. So was I. The sad thing about it is, I don't know if I was disappointed because I was actually doing the drug or because she caught me."
Odom claims Kardashian, 32, "tolerated" his cocaine use throughout the remainder of their marriage, as it was his "drug of choice."
The former NBA star claimed reality TV stints on Keeping Up With the Kardashians and Khloe & Lamar led to infidelity.
"It also opened this gate up with other women who probably wouldn't have been interested in me," he said. "When I became Khloé Kardash-ian's man and on TV, it made me look more enticing. People who didn't even know basketball would approach me because they knew Lammy."
Odom admitted, "b****s and THOTs came out of the woodwork."
"If there is one thing I regret when I was married, it was having multiple affairs with different women," he confessed. "That wasn't the stand-up thing to do. I wish I could have kept my d**k in my pants."
Odom reveals he "turned the drug use up to another level" with late friend Jamie Sangouthai when Kardashian filed for divorce in December 2013.
"I was in a very dark place and very confrontational," he said. "I wasn't trying to repair my marriage; I was just trying to get high. My life was all about drugs at that point. It probably helped the end of my career come along a little faster because drugs killed my drive to want to train and be in shape. It killed that and my sex drive. The only time you can f**k is when you take coke."
Odom ended up at the brothel because he was "bored."
"I wanted to get out and have a good time," he said. "Looking back, I might have had a drink to get the mood started, but was I drunk or on drugs? Not at all. I remember lying in bed. Two women were in bed and then I fell asleep. That's all. When I woke up four days later, I was trying to pull the tubes out of my mouth."
Although Odom denied drug use, a Nevada Sheriff told L.A. Times he had taken cocaine and 10 doses of herbal Viagra before he was found unconscious.
The father-of-two says it was a "moment of relief" when Kardashian helped him through his recovery, where he suffered 12 strokes and two heart attacks after being found comatose.
"I didn't even know what had just happened," he said of waking up in the hospital. "She was the first thing I saw. She played a major role in me getting my memory back. She would bring pictures of my mother and my grandmother. I kept thinking, Am I paralyzed forever? Am I mute forever?"
Odom explained how he didn't try to reconnect with Kardashian romantically during that time.
Odom completed a stint at San Diego's Casa Palmera rehab center in January after his daughter Destiny, 18, gave him an ultimatum.
"She said, 'Pops, you get help or I won't talk to you,'" he said. "I think she saw it in my behavior. Coke is a real psychological drug. My kids were really scared that their dad wasn't going to be here."
He admitted that he is sober from drugs. He is currently working on a docu-series and autobiography.
"Being in the moment is important — how you react, respond, create," he said. "If I would have done coke last night, you would have gotten some dickhead here trying to get out of here fast. But you're getting Lamar now."
We pay for juicy info! Do you have a story for RadarOnline.com? Email us at firstname.lastname@example.org, or call us at (866) ON-RADAR (667-2327) any time, day or night.