The 56-year-old Fuller House actress was spotted at the Cabo San Lucas, Mexico airport with the 58-year-old fashion designer on Thursday.
As Radar reported, a judge gave the couple permission to leave the country while on probation following the college admissions scandal.
Despite being south of the border, Loughlin and Mossimo couldn't stay out of the limelight.
Paparazzi were at the airport waiting to capture the first shots of the duo, who will be in Mexico until Monday.
Loughlin looked ready for some rest and relaxation. The disgraced star was seen wearing a straw fedora, a pink t-shirt, and a pair of olive green cargo pants.
It appears she's gone blonde for the Mexico vacation too. Her lighter highlights stood out in the sunshine.
Mossimo kept it casual for the plane ride. He sported a dark-colored button-up, matching pants, and a white trucker hat.
While their outfits screamed vacation, their faces did not.
Loughlin and Mossimo showed no emotion as they walked past the nearby shutterbugs and into their car.
As Radar reported, the Fuller House actress and the fashion designer begged the judge in their college admissions scandal to sign off on their travel requests last month.
The convicted criminals were granted permission to take their daughters -- Isabella, 22, and Olivia, 21 -- to San Jose del Cabo from June 16 to June 21.
They begged the judge to allow them to get the hell out of Dodge for some quality family time.
Loughlin was quick to point out that she's played by the rules since being released from prison at the end of last year.
"Ms. Loughlin has remained in compliance during her term of supervised release," her request letter stated.
It also said she had presented herself "respectfully" and "cooperatively" during every interaction with her probation officer.
Loughlin added that she had "satisfied her fine" of $150,000 and completed all of the community service hours she was given.
The judge wasn't the only person who thought Loughlin and Mossimo should go on vacation.
The actress's probation officer was actually on board with the family's trip down south too.