The 56-year-old Fuller House actress and her 58-year-old fashion designer husband were photographed looking relaxed and beyond happy during their time in Cabo San Lucas, Mexico.
Loughlin was seen whopping it up in a pool surrounded by several males who were drinking beer.
Wearing a white caftan dress and a large hat to shield her face from the sun, the ex-Hallmark star was full of smiles while chatting it up with the couple's friends.
At one point, Loughlin even got out her binoculars and waved to cameras, seeming giddy to soak up the attention.
As for Mossimo, he indulged in a day of golf with the guys.
He was spotted slipping out of his swim trunks and into his golf gear for a day on the greens.
Meanwhile, they seemed to have left their daughters -- Isabella, 22, and Olivia, 21 -- behind in Los Angeles, despite being approved by the judge for a "family vacation."
On Tuesday, Olivia jumped onto her Instagram Stories to document her regular day at home.
She showcased herself cuddling her dog in bed, and tried on several outfits that were gifted to her by Frankies Bikinis.
Her older sister has remained silent on social media.
Loughlin and Mossimo touched down in Mexico over the weekend, marking their first post-prison vacation.
As Radar reported, a judge gave the couple permission to leave the country while on probation following the college admissions scandal.
The duo begged the judge to sign off on their travel requests last month; however, they hawked the trip as a family vacation.
In documents obtained by Radar, Loughlin asked for permission to travel from June 16 to June 21 "to spend time with her family."
The Fuller House actress was quick to point out that she's played by the rules since being released from prison at the end of last year.
The documents also stated she had presented herself "respectfully" to her probation officer, "satisfied her fine" of $150,000, and completed her required community service.
A judge signed off on Loughlin and Mossimo's trip on May 20.