Though Jenner didn't offer an explanation for the show's end, RadarOnline.com previously reported that the onetime Olympian, 66, wasn't pulling in the ratings E! had come to expect from their other hits, including ex-wife Kris' longtime series Keeping Up with the Kardashians.
"There just weren't enough viewers," a production insider said earlier this month. "The show can't compete with other programming."
The source also claimed the LGBT community didn't relate to the staunch Republican, and often didn't believe she was standing up for their rights in an increasingly hateful country.
"Trans viewers did not see her as one of them," the insider sighed.
I Am Cait, which featured Jenner's famous gal pals Candis Cayne and Jennifer Finney Boylan, premiered last summer in an effort to educate viewers about the star's very public gender transition.