The 30-year-old was admitted to the hospital on March 13 after a bodyguard found him unconscious on the floor just hours after he was released from the hospital following multiple seizures the day before.
"I'm good everybody. Thx for the prayers and love," Lil Wayne tweeted last Friday, but remained in the hospital for another three nights.
The president of Lil Wayne's music label Young Money, Mack Maine, tweeted on Monday night, "Thanks to Cedar Sinai for everything!!! @LilTunechi (Lil Wayne) has been officially been released and is headed home....God is great."