While the cast of ER has always been up front and center, through the years a handful of other recognizable names and faces have gone through the hospital doors.
As we bid a fond farewell to the groundbreaking drama, click here for a gallery of the best celebrity guest spots.
Some highlights: Kirsten Dunst plays a troubled teenager soothed by George Clooney, a post Sex and the City Cynthia Nixon plays a stroke victim, and Ewan McGregor is a convenience store gunman!
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The final episode of ER airs tonight at 8/7c on NBC.