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Christina Applegate to Letterman: "There's Comedy In Illness"

Mar. 26 2009, Updated 12:45 p.m. ET

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Samantha Who’s Christina Applegate’s can now freely joke about her double mastectomy last year.

On Wednesday night’s Late Show With David Letterman, Letterman cautiously asked the actress whether she was comfortable talking about her medical scare. The actress pretended not to know what he was talking about, but then opened up to Letterman and announced she was great and passed her last exam with flying colors.

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Applegate tells Letterman in the clip, "there’s comedy in illness" and described how funny moments in her seven day hospitalization helped her get through it all.

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