According to the White House, Melania, 48, had been experiencing an issue with her kidney that required medical attention. The surgery was deemed successful and her condition was described as "benign."
Melania entered Walter Reed National Military Medical Center in Bethesda, Maryland on Monday morning and is expected to remain in the hospital for several days following the operation.
She is the first US first lady to undergo a serious medical procedure while in the White House since Nancy Reagan's mastectomy in October 1987.
CNN was first to report the news.
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