The 'Suburbicon' star is not a fan of entertainment figures entering politics.
She said: "I can't bear the thought of President Clooney.
"'I can't bear it, this idea of relating leaders with entertainment figures'
"What you want is a president who is experienced in government. I don't even want to joke about movie stars being president of the US.'
New dad Clooney – who also directed Suburbicon – has reportedly taken more of an interest in entering the political arena recently.
There is growing speculation that the actor and activist would like to run for the White House.
However, it is his role as a new dad and husband to, Amal Clooney, that has really impressed Moore.
She added: "You can see the difference in his personality, how settled he seems… he adores Amal."
Moore, 56, is happily married to her husband of 14 years Bart Freundlich – she has two children Liv and Caleb.
We pay for juicy info! Do you have a story for RadarOnline.com? Email us at email@example.com, or call us at (866) ON-RADAR (667-2327) any time, day or night.