49ers vs. Seahawks Thanksgiving Predictions: Data Insights and Best Bets for NFL Week 12

San Francisco 49ers running back Christian McCaffrey, right, tries to get past Tampa Bay Buccaneers safety Antoine Winfield Jr. during the first half of an NFL football game Sunday, Nov. 19, 2023, in Santa Clara, Calif. (AP Photo/Godofredo A. Vásquez)

By:Mac Douglass

Nov. 23 2023, Published 3:06 a.m. ET

The San Francisco 49ers and Seattle Seahawks duke it out in an NFL Week 12 matchup at Lumen Field on Thanksgiving Day. Kickoff is at 8:20 p.m. EST.

Get the inside scoop with this 49ers vs. Seahawks betting guide, which features the latest betting odds and insider tips you need to make the most of this game.

According to the latest odds from Bet365, the 49ers are the favored team against the Seahawks on Thursday. The over/under for total points scored is set at 43.5.

49ers vs. Seahawks 2023 Preview

When and Where

Teams: San Francisco 49ers
Date: Thursday, November 23, 2023
Time: 8:20 p.m. EST
Venue: Lumen Field

Odds and Lines

Point spread: 49ers -7 (-108), Seahawks +7 (-105)
Moneyline: 49ers -325, Seahawks +280
Total: Over/Under 43.5 (-115/-105)

Please note that the odds and lines mentioned in this article are the best available at the time of publishing but are subject to change.

49ers vs. Seahawks Prediction

Radar Sports has teamed up with Dimers.com to run a whopping 10,000 simulations of the 49ers vs. Seahawks game using trusted data and computer power to predict the most likely scenarios for your benefit.

Let's cut to the chase – who's going to win? According to Dimers' cutting-edge computer model, the 49ers have a 72% chance of winning against the Seahawks at Lumen Field.

Furthermore, the model predicts that the Seahawks (+7) have a 57% chance of covering the spread, while the over/under total of 43.5 points has a 52% chance of going over.

Best Bet for 49ers vs. Seahawks

Our free computer pick for the 49ers vs. Seahawks game on Thursday is to bet on the Seahawks +7 (-105).

All of the tips in this article are based on world-class simulations and hundreds of data points to serve you the best possible plays.

49ers-Seahawks Week 12 Player Props

First Touchdown Scorer Probabilities

San Francisco 49ers

Christian McCaffrey: 18.6% probability
Brandon Aiyuk: 10.5% probability
George Kittle: 8.9% probability
Deebo Samuel: 8.6% probability
Elijah Mitchell: 3.3% probability

Seattle Seahawks

Zach Charbonnet: 8.5% probability
Tyler Lockett: 7.2% probability
DK Metcalf: 6.9% probability
Jaxon Smith-Njigba: 5.1% probability
Geno Smith: 3.2% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

Christian McCaffrey: 64.1% probability
Brandon Aiyuk: 42.1% probability
George Kittle: 36.2% probability
Deebo Samuel: 35.7% probability
Elijah Mitchell: 15.7% probability

Seattle Seahawks

Zach Charbonnet: 35.9% probability
DK Metcalf: 31.2% probability
Tyler Lockett: 30.7% probability
Jaxon Smith-Njigba: 24.2% probability
Geno Smith: 14.9% probability

49ers vs. Seahawks Score Prediction

Radar Sports' crystal ball for San Francisco vs. Seattle at Lumen Field has the 49ers winning 25-19.

This prediction is based on both teams' average score after 10,000 game simulations.

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About the Author

Mac Douglass is the Senior Sports Betting Editor at Cipher Sports Technology Group. In addition to covering the sports betting industry for several news sites across the US, Mac provides sports analysis and betting tips for Dimers and tennis commentary for Stats Insider.