The topic of discussion leading up to the volatile moment between co-hosts on Thursday was President Joe Biden's recent clash with a reporter at a press conference, for which he immediately apologized.
Goldberg said she never saw the same type of remorse or accountability from former President Donald Trump.
"The thing that I never saw Trump do was apologize to anybody, and I will take it because sometimes I'm rude to somebody. We're all like that," she said, before McCain interrupted her.
"With all due respect... With all due respect..." Meghan said loudly over Whoopi, who responded by asking her co-host to let her finish what she was saying.
"With all due respect, I don't care if he's apologizing," Meghan continued anyway. "He just embarrassed himself. And you don't like Trump."
Whoopi fired back, "I don't care that you don't care. Just hear what I'm saying." But Meghan would not. "I don't care that you don't care, Whoopi! So we're even," she said, rolling her eyes.
"Well then good, Meghan, then you can be how you always are," Goldberg said, trying to wrap up the segment. "We'll be right back."
But McCain managed to squeeze in a "Be how you always are!" before cameras cut to a commercial break.
During the Wednesday press conference, CNN's chief White House correspondent Kaitlan Collins was the last person to get a question in, asking POTUS what made him so confident that Russian President Vladimir Putin might change his behavior in regard to cyber-security and human rights violations.
Biden recently met with Putin at a summit in Geneva.
"I'm not confident he'll change his behavior," Biden told Collins. "Where the hell – what do you do all the time? When did I say I was confident?"
"What I said was – let's get it straight – I said, 'What will change their behavior is if the rest of the world reacts to them and it diminishes their standing in the world,'" he added. "I'm not confident of anything. I'm just stating a fact."
Collins then pointed out that Putin had denied his involvement with cyber-attacks and breaches, and also downplayed the topic of human rights abuses. "How does that amount to a constructive meeting?" she asked.
Biden fired back, "If you don't understand that, you're in the wrong business." He then left the stage.
However, before departing Geneva on Air Force One, a calmer POTUS told reporters he owed the reporter "an apology."
"I shouldn't have been such a wise guy with the last answer I gave," he said.
Speaking later with network colleagues, Collins said, "That is completely unnecessary from the President. He did not have to apologize, though I do appreciate that he did there in front of the other reporters as he was about to get on Air Force One to go back to Washington."