The 67-year-old star laughed off the rumors surrounding her status with the Duke and Duchess of Sussex's second child, Lilibet Diana Mountbatten-Windsor.
Speaking to Entertainment Tonight, Oprah shut down the speculation and joked that she's already their daughter's godmother by "default."
"I don't need to be a godmother. I'm a godmother by default," the legendary talk show host told the outlet.
Not only has Harry teamed up with Oprah for the couple's explosive sit-down and their project with Apple TV+, but he and his wife also moved into the star's exclusive Monticeito neighborhood into a $14 million mansion.
"I'm a neighbor, I'm a friend and all that, you probably need someone younger to be the godmother," Oprah insisted.
When it comes to Harry and Meghan's controversial baby name, Oprah said she was a huge fan of the couple's choice.
She also revealed she had got her neighbor Harry a special gift for Father's Day.
As Radar reported, Harry and Meghan received backlash after announcing Lilibet's unique name following her birth.
They explained the reasoning behind their choice in a statement from their press secretary.
"Lili is named after her great-grandmother, Her Majesty The Queen, whose family nickname is Lilibet. Her middle name, Diana, was chosen to honor her beloved late grandmother, The Princess of Wales," their statement read.
However, there's been speculation regarding whether Harry got permission from Queen Elizabeth to use her childhood nickname.
As Radar reported, Harry threated legal action against the BBC for publishing a report that he and Meghan didn't consult the Queen prior to naming their daughter.
Hours after the outlet claimed they were told by Senior Buckingham Palace sources the Queen was "never asked" by the couple to use her cherished nickname for their baby, an angry Harry hit back.
Harry also insisted they would never use the name without the Queen's permission.