The 36-year-old Keeping Up With The Kardashians star took to her social media just hours after the explosive claims and dropped a cryptic message.
Sharing a lengthy quote from writer Stephanie Bennett-Henry, Khloé's post tugged at her followers' heartstrings.
"I'm at peace because I know I was always true, had the best intentions, came from a good place with all of my heart, and I with the very best to everyone, even the ones who wanted nothing more than to spotlight the ugliest parts of me, still I wished them well. I always will," it read.
"I hold blessings for everyone, but especially for the ones who wanted nothing more than to see my light turn dark. Why? Because they need it the most."
The emotional quote ended with a powerful send-off, signifying that KoKo is just fine without Tristan.
"My peace... it is mine. It's personal, unbreakable and I guard it with my life, because for the life of me, I earned this S---," it read. "You cannot break through my light. You cannot shake my peace. It's mine."
Khloé's post on her Instagram Stories came just hours after Daily Mail reported Tristan was caught sneaking into a bedroom with three girls at a party in Los Angeles over the weekend.
Partygoers allegedly told the outlet, Tristan arrived at the party for Drake's bodyguard and headed straight to the bar for tequila shots.
Witnesses claim the NBA star disappeared into a bedroom with three women then reappeared 30 minutes later looking "disheveled."
While KUWTK fans felt sympathy for Khloé, Page Six claimed the duo actually broke up weeks ago.
It's a convenient narrative considering Khloé and Tristan looked pretty cozy at lunch together with their daughter, True, last week.
"They’re getting along. There is no drama. Everything is amicable and they are on the same page with co-parenting," the insider said.
This isn't the first time he's been accused of cheating on Khloé this year.
23-year-old Sydney Chase claimed she hooked up with Tristan earlier this year and he reportedly said Khloé wasn't his "type."
While the NBA star denied he cheated with Sydney, the model was prepared to expose receipts and hired powerhouse attorney Gloria Allred.
Following the latest cheating allegations, Allred spoke to Radar and said she's "not surprised" he may have strayed again.
As of this post, Tristan has yet to comment on the rumors.