The 34-year-old is expecting her first child with husband Christopher Robin.
Knox -- aka Foxy Knoxy -- announced the exciting news on her podcast Labyrinths: Getting Lost With Amanda.
The criminal justice activist is pregnant with her rainbow baby, just one month after revealing she had suffered a miscarriage.
Podcast listeners will get a play-by-play of Knox's pregnancy experience too.
"That’s right, we’re pregnant," she shared on Wednesday. “We’ve been recording audio of our own experience since day one. Stay tuned for our next mini-series, 280 days, where we take you on an intimate journey from conception to birth.”
Knox recalled her excitement after seeing those “three bars" on her pregnancy test.
“Yes! Thank goodness. We did it!” she remembered screaming out loud.
In July, Knox broke down in tears while opening up about her miscarriage.
“We sat with the miscarriage for a while trying and failing to be OK," she said in the Season 2 epsidoe.
Knox stated the baby "didn’t have a heartbeat" and she had "experienced abdominal pain like [she had] not experienced before."
She recalled beating herself up, trying to find a reason behind the miscarriage.
“I thought I knew exactly what I want to do with my first pregnancy and [to] have it not come to fruition, not through choice, felt like a betrayal. Do I have bad eggs? Am I too old? Did something happen to me while I was in [prison in] Italy?" she asked.
Soon, Knox knew that she had to move forward.
"As soon as I learned it wasn’t alive, I tried to divorce those two ideas in my head, that was not my baby, it doesn’t have a name. … I don’t know that baby, I don’t think I ever will," she told her podcast listeners.
Knox and Robin got engaged in November 2018.
In December 2009, Knox and her former boyfriend Raffaele Sollecito were convicted of Kercher's murder.
Their convictions were overturned in 2013, but they were convicted again the following year.
Knox and Sollecito's convictions were overturned for a final time in 2015.