Of Donald Trump, the funnyman said, "People are asking, 'will Donald Trump run again?' And the answer is, 'does that thing on his head crap in the woods?'"
Jessica Simpson, who was in the audience, didn't escape McKale's razor-sharp humor. He called President Obama "one of the
all-time great presidents. Definitely among the top 50. Somebody please explain that to Jessica Simpson."
Arguably the best line of the night though was aimed at Kim Kardashian and her sisters.
Said McKale: "I know the Kardashians are Republicans because they're always trying to screw black people."