VIDEO: David Letterman Tattoos Jesse James With Wisecrack

It might be out of respect to Sandra Bullock, or it could be because of his own well-documented liaisons, but David Letterman hasn’t tapped into potential comedy treasure chest that is the Jesse James cheating scandal — until now.

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On Monday’s The Late Show, Letterman cracked a joke at James’ expense.

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“According to a new study, human beings bred with Neanderthals,” Letterman said. “Well, that certainly didn’t work for Sandra Bullock!”

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As has previously reported, Letterman had to juggle his own scandal last fall, coming clean on his show that he cheated on wife Regina Lasko with a staffer after an ex-CBS producer blackmailed him with the information; he dubbed his infidelities “stupid behavior” in an interview last month.

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