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49ers vs. Steelers Prediction, Odds for NFL Week 1

49ers vs Steelers Prediction.

49ers vs. Steelers prediction and betting preview.

Sep. 10 2023, Published 7:45 a.m. ET

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The San Francisco 49ers and Pittsburgh Steelers will face off in an NFL Week 1 matchup at Acrisure Stadium on Sunday. The game will start at 1 p.m. ET.

Get the inside scoop with this 49ers vs. Steelers betting preview, which contains the latest betting odds and our best bet of the game.

According to the latest odds from Bet365, the 49ers are favored to win against the Steelers on Sunday. The over/under for total points scored is set at 41.5.

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49ers vs. Steelers 2023 Preview

When and Where

  • Teams: San Francisco 49ers vs. Pittsburgh Steelers
  • Date: Sunday, September 10, 2023
  • Time: 1 p.m. ET
  • Venue: Acrisure Stadium

Odds and Lines

  • Point spread: 49ers -2 (-110), Steelers +2 (-110)
  • Moneyline: 49ers -130, Steelers +115
  • Total: Over/Under 41.5 (-110/-110)

Please note that the odds and lines mentioned in this article are the best available at the time of publishing but are subject to change.

49ers vs. Steelers Prediction

Radar Sports has teamed up with to run a whopping 10,000 simulations of the 49ers vs. Steelers matchup using independent machine learning to predict the most likely outcomes for your benefit.

Drumroll, please! According to Dimers' cutting-edge computer model, the 49ers have a 63% chance of beating the Steelers at Acrisure Stadium.

The model also predicts that the 49ers (-2) have a 58% chance of covering the spread, while the 41.5-point over/under is considered an equal 50-50 chance of hitting.

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Keep in mind that the predictions and probabilities in this article are correct at the time of publishing and subject to change.

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Best Bet for 49ers vs. Steelers

Our free data-driven pick for the 49ers vs. Steelers game on Sunday is to bet on the 49ers moneyline (-130).

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All of the tips in this article are based on world-class predictive analytics and hundreds of different factors to serve you the best possible plays.

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49ers-Steelers Week 1 Player Props

An enjoyable option to wager on San Francisco vs. Pittsburgh without necessarily betting on the game's outcome is through player props.

The most likely first and anytime touchdown scorers for the 49ers and Steelers can be seen below.

According to our model, San Francisco's Christian McCaffrey has the best chance of scoring the first touchdown in 49ers vs. Steelers.

McCaffrey has a 13.3% chance of scoring the opening TD on Sunday. The 49ers RB has a 49.9% probability of registering an anytime touchdown.

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First Touchdown Scorer Probabilities


San Francisco 49ers

  • Christian McCaffrey: 13.3% probability
  • Deebo Samuel: 8.4% probability
  • Brandon Aiyuk: 7.8% probability
  • George Kittle: 6.8% probability
  • Elijah Mitchell: 6.4% probability

Pittsburgh Steelers

  • Najee Harris: 9.9% probability
  • George Pickens: 6.9% probability
  • Diontae Johnson: 5.8% probability
  • Pat Freiermuth: 5.4% probability
  • Jaylen Warren: 5.2% probability
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Anytime Touchdown Scorer Probabilities

San Francisco 49ers

  • Christian McCaffrey: 49.9% probability
  • Deebo Samuel: 33.0% probability
  • Brandon Aiyuk: 31.6% probability
  • George Kittle: 28.8% probability
  • Elijah Mitchell: 26.4% probability

Pittsburgh Steelers

  • Najee Harris: 39.8% probability
  • George Pickens: 28.1% probability
  • Diontae Johnson: 24.9% probability
  • Pat Freiermuth: 23.7% probability
  • Jaylen Warren: 22.7% probability

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49ers vs. Steelers Score Prediction

Radar Sports' crystal ball for San Francisco vs. Pittsburgh at Acrisure Stadium has the 49ers winning 22-19.

This prediction is based on both teams' average score after 10,000 game simulations.

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The Final Word on 49ers vs. Steelers

Sunday's NFL Week 1 matchup between the 49ers and Steelers on Sunday is scheduled to start at 1 p.m. ET.

If you liked this 49ers vs. Steelers preview, you're going to love our other offerings!

In collaboration with, Radar Sports provides a range of exciting content. You can explore the latest NFL betting news or delve into our curated NFL best bets and well-informed NFL predictions covering all the games. And don't miss our expertly selected Super Bowl picks designed to enhance your futures betting experience.

All the predictions and probabilities in this article are based on 10,000 data-driven simulations of Sunday's 49ers vs. Steelers matchup and are correct at the time of publishing to help you make better decisions when placing an online bet.

Sports betting can be exciting, but it's crucial that you bet responsibly and manage your bankroll effectively.

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About the Author

Ben Tufts is a sports betting writer and reporter for Cipher Sports Technology Group, and regular contributor to several prominent industry websites, including, lauded for their data-driven predictive sports analytics. Known for co-creating and co-hosting an award winning sports talk podcast, Ben graduated magna cum laude from Quinnipiac University with a bachelor of arts degree in media studies, Ben's expertise lies in the NFL, MLB, NHL, and NBA, as well as sports betting industry politics. His passion for sports and sports betting, combined with his diligent, methodical reporting and research, set Ben apart as a valuable asset to the sports betting community.



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