“Dennis was not faithful to me for a long time,” Meg Ryan of her marriage to actor Dennis Quaid. Ryan retaliated by having a high-profile affair with Russell Crowe in 2000, resulting in her divorce from Quaid.

Ethan Hawke was reported to have cheated on his then-wife Uma Thurman after assuming that she was having an affair with her Kill Bill director Quentin Tarantino. They divorced in 2004.

Rumors surfaced in 2006 that actor Josh Hartnett had been spotted cheating on girlfriend Scarlett Johansson with an unidentified woman in Sydney, Australia while Johansson was filming in England.

Backstreet Boy Nick Carter cheated on then-girlfriend Paris Hilton with Ashlee Simpson after he’d heard rumors that Paris was sleeping with her House of Wax co-star, Chad Michael Murray.

While engaged to actress Sienna Miller in 2005, Jude Law cheated on her with his children’s former nanny, Daisy Wright.

Dave Navarro reportedly has a Las Vegas fling while married to then-wife Carmen Electra with actress Jenae Alt.

Jesse James was ousted as allegedly having multiple affairs on Sandra Bullock just 10 days after she won her first Academy Award for The Blind Side. So far Jesse is up to four mistresses!