River Phoenix-Big brother to Oscar nominee Joaquin Phoenix, River died of a drug overdose at the age of 23.

James Dean-50’s Screen Icon James Dean died in a car accident when he was in the midst of great career success, he was 24.

John Belushi-Older brother of James Belushi, John was found dead in his room at the famed Chateau Marmont Hotel in West Hollywood. He died from a drugs overdose, he was 33.

Brandon Lee-Son of the legendary martial artist Bruce Lee, Brandon died following a tragic on-set accident while he was filming The Crow. He was 28.

John Candy-Funnyman John Candy died in his sleep from a heart attack. He was 43.

Anna Nicole Smith-Playboy centerfold Anna Nicole Smith died from a drugs overdose at the age of 39. Smith’s former attorney, and husband, Howard K Stern is currently facing trial in relation to her death.

Chris Farley-SNL star Chris Farley had struggled with his weight throughout his life. He was discovered dead in his apartment. Farley had died of a heart attack and in addition had overdosed on cocaine and morphine. He was 33.

Dana Plato-Sitcom actress Dana Plato died from an overdose of Vicodin and Vanadom. She was 34 years old. Her death was ruled suicide.

Heath Ledger-Heath Ledger tragically was found dead in his New York apartment following an accidental overdose of various prescription drugs. He was 28.

Brittany Murphy-Brittany Murphy’s untimely death was caused by pneumonia with secondary factors of iron-deficiency anemia and multiple drug intoxication. The actress was 32.

Corey Haim died at the age of 38 from a drug overdose on March 10, 2010.