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3. Get Really High
An acid trip's a daydream compared with the mind-blowing shit you'll experience after licking an Amazonian tree frog. The enzymes secreted through its skin are best enjoyed in the company of experts, like former High Times editor Peter Gorman, who leads psychedelic sojourns into the jungle from his Cold Beer Blues Bar in Iquitos, Peru.

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4. Blow Lines
The world's best Bolivian marching powder is dirt cheap and yours for the snorting in (you guessed it!) Bolivia, a country whose president, Evo Morales, himself once worked the fields picking the U.S.'s favorite South American cash crop. While copping a kilo of the uncut stuff still requires a bit of back-alley haggling, less-potent coca products—coca tea, coca leaves, coca wine—are legally stocked in La Paz's finest boutiques.